Description

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Iboga

Scientific Name(s): Tabernanthe iboga Baill.
Common Name(s): Bitter grass, Iboga, Ibogaine, Leaf of God, Thie-pelakano

Use

Iboga has been used ritually as a hallucinogen. Studies suggest that ibogaine, one of the iboga alkaloids, has potential in the treatment of addiction to several substances. The US Drug Enforcement Agency (DEA) has placed ibogaine into Schedule I of the Controlled Substances Act (CSA).

Benefits of Iboga

Drug abuse. Early evidence suggests that ibogaine, a chemical in iboga, can help increase abstinence and relieve withdrawal symptoms in people abusing drugs such as heroin, codeine, cocaine, and other substances such as alcohol, tobacco, and marijuana.
Addictions.
Fever.
Flu.
HIV/AIDS.
High blood pressure.
Nerve disorders.
Preventing fatigue and drowsiness.
Other conditions.

Dosing

Strict medical supervision is necessary. Ibogaine has been used in single doses of 500 to 800 mg in a clinical study, and 17 mg/kg in a drug dependency treatment center.

Contraindications

Fatalities have been associated with the use of ibogaine; concomitant opioid use and comorbidities (eg, cardiovascular disease, depression, posttraumatic stress disorder, anxiety, stress, schizophrenia, epilepsy, or other imbalances in the autonomic nervous system) increase the risk of life-threatening complications including sudden cardiac death. Ibogaine should only be used under the supervision of an experienced health care provider.

Adverse Reactions

Mild acute effects occur frequently and include nausea, vomiting, ataxia, tremors, headaches, and mental confusion. Manic episodes lasting 1 to 2 weeks have also been reported and manifested as sleeplessness, irritability, impulsivity, emotional lability, grandiose delusions, rapid tangential speech, aggressive behavior, and suicidal ideation.

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Toxicology

Large doses of iboga can induce agitation, hallucinations, vomiting, ataxia, muscle spasms, weakness, seizures, paralysis, arrhythmias, urinary retention, respiratory insufficiency, and cardiac arrest.

Uses and Pharmacology

The effects of iboga may be dose dependent. Low doses appear to act on the cerebella to stimulate the sympathetic nervous system, as well as increasing muscle strength and endurance, and are used among indigenous African populations as an aphrodisiac and to increase mental alertness and endurance when hunting. Higher doses lead to vagal dominance and induce psychedelic effects and a “feigned death;” users report a state of dreaming without loss of consciousness. Large doses induce hallucinations; however, this dose is close to the level of toxicity and is avoided by traditional users.

Drug addiction

Initial investigation resulted from anecdotal reports of self-treated addicts who experienced a marked lack of desire to continue with opiate abuse following iboga ingestion. Subsequently, ibogaine and 18-methoxycoronaridine have been studied for the treatment of drug addiction.